Dr Sophie Legge
Research Associate, Division of Psychological Medicine and Clinical Neurosciences
- leggese8@cardiff.ac.uk
- +44 (0)29 2068 8837
- 2.30, Hadyn Ellis Building, Maindy Road, Cardiff, CF24 4HQ
Overview
My research is primarily focused on the contribution of genetic and environmental factors to the development of psychosis and schizophrenia.
I am interested in dissecting the heterogeneity and dimensionality of schizophrenia by identifying biologically valid phenotypic constructs.
I am also interested in pharmacogenetics, specifically in relation to clozapine use and the Duffy-null genetic variant. My PhD (completed in 2016) was focused on identifying predictors of treatment-resistant schizophrenia, and the genetic causes of clozapine-induced neutropenia, a rare adverse effect of the antipsychotic clozapine.