Professor David Lloyd
Honorary Professor
Overview
Research Overview
Studies in Professor David Lloyd's Laboratory include:
- Biological timekeeping especially in the range seconds to hours in living organisms
- Monitoring intracellular events by non-invasive methods such as mass spectrometry, fluorescence techniques and NMR
- Using these approaches to solve medical, environmental and industrial problems
- Microwave interactions with biological systems: separated electric and magnetic field effects, and putative non-thermal components.
Biography
Timeline
- 2015 - present Collaboration with US National Institute of Health on Aging, Baltimore, USA
- 2008 - present Honorary Professor (Cardiff University)
- 2008 – 2017 H.C. Andersen Professor of Biochemistry and Molecular Biology, (University of Southern Denmark, Odense, Denmark)
- 2001 - present Collaboration with Department of Molecular Cardiobiology, Johns Hopkins Medical University, Baltimore, USA
- 1978 - 2008 Professor of Microbiology (Cardiff University)
- 2001 - 2009 (six 1 week visits) Johns Hopkins University, Baltimore, USA, Department of Molecular Cardiobiology
- 1999 (6 months) University of New South Wales, Australia, Department of Biochemistry
- 1998 - 2009 (4 visits) AIST, Tsukuba City and Keio University, Japan
- 1998 (3 months) Tata Institute of Fundamental Research, Mumbai, India, Department of Molecular Biology
- 1997 (3 months) University of New South Wales, Australia, Department of Biochemistry
- 1990 (4 months) Odense University (U.S. Denmark), Department of Biochemistry
- 1986 (2 months) Harvard University, Biolabs, USA
- 1985 (2 months) ATOMKI Debrecen, Hungary
- 1984 (1 month) INRA Bordeaux, France
- 1982 - 1987 Head of the Microbiology Department, University College Cardiff, University of Wales
- 1978 Personal Chair (University College of South Wales & Monmouthshire)
- 1976 - 1978 Reader (University College of South Wales & Monmouthshire)
- 1977 Guest Scientist (2 months) Rockefeller University, New York, USA
- 1976 Senior Lecturer (University College of South Wales & Monmouthshire)
- 1972 DSc (Sheffield)
- 1969 - 1976 Lecturer (University College of South Wales & Monmouthshire)
- 1968 - 1979 (4 visits Wellcome, Leverhulme & RS) University of Pennsylvania, USA
- 1967 University of Pennsylvania, Philadelphia, USA, Department of Biophysics
- 1967 - 1969 Research Assistant MRC Group (Microbial Structure & Function)
- 1964 - 1967 ICI Research Fellowship (University College of South Wales & Monmouthshire)
- 1964 PhD (Wales) (University College of South Wales & Monmouthshire)
- 1961 BSc (Biochemistry, 1st Class Hons) (Sheffield University)
Honours and awards
- Lifetime award: British Society of Protozoology
- Lifetime award: International Society of Protistology
- Fellow of the Learned Society of Wales
- 2008-present Honorary Professor, Cardiff University
- 2008-2017 H.C. Andersen Professor of Biochemistry and Molecular Biology, University of Southern Denmark, Odense
Academic positions
- 1978-2008 Professor of Microbiology, Cardiff University
- 1982-1987 Head of the Microbiology Department, University College Cardiff, University of Wales
- 1978 Personal Chair, University College Cardiff, University of Wales
- 1976 -1978 Reader, University College of South Wales & Monmouthshire
- 1977 Guest Scientist (2 months) Rockefeller University, New York
- 1976 Senior Lecturer, University College of South Wales & Monmouthshire
- 1969-1976 Lecturer, University College of South Wales & Monmouthshire
- 1967-1969 Research Assistant MRC Group (Microbial Structure & Function), University College of South Wales & Monmouthshire
- 1964-1967 ICI Research Fellowship, University College of South Wales & Monmouthshire
Publications
We are currently unable to retrieve the list of publications. Visit our institutional repository.Current Research
- Biology of the flagellate fish parasite, Spironucleus vortens (with Professor Jo Cable, BIOSI)
- Newly-synthesised fluorophores and phosphors as biological optical imaging agents [with Dr Simon J. A. Pope, Dr Ian A. Fallis and Dr Angelo J. Amoroso (Chemistry), Dr Catrin F. Williams (Engineering and BIOSI), and Dr Anthony J. Hayes (BIOSI Confocal)]
- Biological effects of microwaves with Dr Catrin F. Williams (Engineering and BIOSI) and Professor Adrian Porch (Engineering)
- Coupling of oscillatory behaviour in yeasts by intracellular water dynamics with Dr Lars Folke Olsen and Professor Luis A. Bagatolli (University of Southern Denmark)
Grants
Work supported by
- EU Funding
- NERC
- BBSRC
- Wellcome
- The Royal Society
- Ser Cymru
Collaborations
- US National Institute of Health on Aging, Baltimore, USA 2015 - present
- Keio University: Institute for Advanced Biosciences at Tsuruoka, Japan 2005
- Johns Hopkins Medical School, Molecular Cardiobiology, Baltimore, USA 2002 to present
- INTECH, Buenos Aires, Argentina 1998
- Sabbatical at University of New South Wales, Australia 1999
- National Institute for Biosciences/Human Technology, Tsukuba Science City, Japan 1997; 1998
- University of New South Wales, Sydney, Australia 1997
- University of Kebansang, Kuala Lumpur, Malaysia 1989
- TATA Institute for Fundamental Research, Bombay, India 1989; 1991; 1993; 1995; 1997; 1998 to present
- Harvard University, USA 1986
- ATOMKI, Debrecen, Hungary 1984
- INRA, Bordeaux, France 1984
- Soviet Academy of Science, Moscow, USSR 1979
- Moscow State University, USSR 1979
- University of Southern Denmark at Odense, Denmark 1978 to present
- Odense University, Denmark 1977; 1978; 1980; 1981; 1983; 1986; 1990; 1994; 1996
- Rockefeller University, USA 1978
- University of Pennsylvania, USA 1967; 1969; 1971; 1975; 1978; 1979
Industrial collaboration with more than 50 companies and institutes.
Associates
Professor Marc Roussel (on sabbatical leave from Lethbridge, Alberta) used membrane inlet mass spectrometry to reveal the strange attractor that underlies the respiratory dynamics of yeast in continuous culture. This required simultaneous monitoring of dissolved H2S, CO2 and O2; 40,000 points at 15s intervals were acquired in a 3 month continuous culture experiment. This is the first unequivocal demonstration of chaotic control in a biological system at whole cell level.
Dr Katey Lemar established mechanisms for the anti-candidal properties of selected garlic components, diallyldisulphide and allyl alcohol produce apoptotic cell death in this organism without being too toxic to humans. This affords a new way of tackling antibiotic resistance; there are no reported incidents of microorganisms becoming resistant to the garlic compounds.
Dr Catrin F. Williams with Neem Biotechnology (Dr David Williams, Dr Gareth Evans, Dr Robert Saunders and Dr MIchael Graz), Professor Jo Cable and Dr Michael P. Coogan studied the biochemistry and infectivity of the protozoan, Spironucleus vortens towards angelfish, especially sensitivity of the parasite to garlic comstituents.
With Professor Adrian Porch (Engineering), Catrin currently studies effects and their mechanisms of 2.45 GHz microwaves on the bioluminescence of the marine bacterium, Vibrio fischeri and on cultured normal and cancerous human cell lines.
Recent Former Associates
Dr Stefanie Scheerer and Dr Francisco Gomez have established a stable continuous culture of Photobacterium fisheri. This can be used as an on-line monitor for toxic compounds (e.g. biocides) in environmental samples including water supplies. Miniaturization will lead to the development of personal protection systems. Effects of microwaves were studied.
Dr Simon Cottrell showed that freeze dried garlic powder is toxic to MRSA, and that synergistic affects in combination with oxycillin may provide a new chemotherapeutic strategy.
Dr Victoria Gray has shown that the morphology of Salmonella typhimurium and poona species is continually dependent on the tyrosine content of the growth medium. Various sources of the peptone used in the complex diagnostic media may be quite unsuitable on account of their tyrosine deficiency. Aflagellate organisms, unrecognisable as the pathogen, result if the medium is unsuitable.
Dr Kristina Harris investigated the effects of difluoro methylornithine on the growth, structure and function of Trichomonas vaginalis. Defective hydrogenosemes are one consequence of this ornithine decarboxylase inhibitor.
Dr Jonathan Wood investigated the application of garlic as an antibacterial specifically against MRSA. Resolution of effects required separation of the main toxic constituents; synergy with penicillin derivatives was researched.
Dr Coralie Millet investigated protozoal fish parasites Hexamita and Spironucleus spp. Market for viticulture of aquarium fish is $7b/an. Pathogenicity and invasiveness; biodiversity was studied and compared with that of free living species.
Supervision
Past projects
Post-Graduate
No. | Name | Dates (Awarded) | Thesis Title (Funding Body) Joint Supervisors |
66 | Heather Chick | 2014-15 (2015) | Antimicrobial activity of Garlic vs. V. fischeri, S. Typhimurium, Burkholderia (KESS studentship) with Colin Berry (BIOSI, Cardiff University) & Neem Biotech Ltd |
65 | Rhodri Williams | 2013-14 (2014 | Antimicrobial activity of Garlic vs. MRSA (Clostridium difficile) (KESS studentship with Martin Day (BIOSI, Cardiff University) & Neem Biotech Ltd |
64 | Catrin F Williams | 2013 | Growth, Metabolism, Biochemistry and Chemotherapy of Spironucleus vortens (EPSRC Studentship) with Dr David Williams (Neem Biotech Ltd) with Jo Cable (BIOSI, Cardiff University) |
63 | Jon Wood | 2009 | Effects of garlic on MRSA with Sue Plummer (Cultech Port Talbot) |
62 | Coralie Millet | 2009 | Growth, metabolism, ultrastructure and chemotherapy of Spironucleus vortens (Morgan Parasitology PG Studentship) with Jo Cable (BIOSI, Cardiff University) |
61 | Stephanie Scheerer | 2008 | Microbial biodeterioration of outdoor stone monuments: Assessment methods and control strategies with Colin Gibson (UWCM) and Cymtox (Cardiff University) |
60 | Kristina Harris | 2007 | Determining the role of polyamine metabolism in two human pathogenic protozoa : Trichomonas vaginalis and Giardia intestinalis (Boehringer Ingelheim Fond and Bateman Trust) with Burt Goldberg (New York University) |
59 | Victoria Gray | 2006 | Growth of Salmonella enterica on diverse media |
58 | Katey Lemar | 2005 | Cell death in the human pathogen Candida albicans: effects of garlic (Allium sativum), and garlic constituents allyl alcohol and diallyl disulphide with Sue Plummer (Cultech Baglan, Port Talbot) |
57 | David Pooley | 2003 | Biological effects of millimeter-wave radiation perturbation of Photobacterium in continuous culture |
56 | Simon Cottrell | 1999-2002 (2003) | Garlic as antibacterial (Cultech) |
55 | Samuel Sheppard | 1999-2002 (2002) | Sludge amendment of soil (NERC) |
54 | Rosemary Fiera | 1998-2001 | Apoptosis and mitochondria (Tenovus) with Ivor D. Bowen (Cardiff University) |
53 | Neil Turner | 1998-2001 | Acanthamoeba infections with A. Denver Russell (Pharmacy, Cardiff University) |
52 | Eshanta Salgardo | 1998-2001 | Fusel oils and oscillations in yeast cultures (Allied Brewers, Burton on Trent) with J.R. Dickinson (Cardiff University) and Allied Brewers (Burton on Trent) |
51 | Janine Harris | 1997-2000 | Garlic and Giardia (Cultech) with Sue Plummer (Cultec, Baglan, Port Talbot) |
50 | Paul Allen | 1997-2000 | Giardia encystation (Thames Water) |
49 | Zoe Matheson | 1997-2000 | Giardia in Water Supplies (Thames Water) |
48 | Ceri Arthurs | 1996-1999 (2000) | Cider lactobaccili with Basil Jarvis (Bulmers) |
47 | Janine Morgan | 1996-1999 | Erythromycin fermentation with R.T. Rowlands (Panlabs Taiwan) and I.H. Gilbert (Dundee University) |
46 | Jonathan Tammam | 1996-1999 | Lactobacilli in Cheese with Alan G. Williams (Hannah Institute, Ayr) |
45 | Angela Berry | 1996-1999 | Peat bog methanogeneis (NERC) with Stuart Davies (Cardiff University) |
44 | Burt Goldberg | 1995-1998 (1998) | Trypanosome metabolism with Nigel Yarlett (PACE University, NY, External) |
43 | Sarah White | 1995-1998 | Cider lactobaccili (MAFF) with Basil Jarvis (Bulmers, Hereford) |
42 | George Cowie | 1995-1998 (1999) | Gases in sediments (NERC) |
41 | Giancarlo Biagini | 1994-1997 (1998) | Anaerobic protozoa free living in sediments (NERC) with Bland Finlay (NERC) |
40 | Marc Suller | 1994-1997 (1998) | Flow cytometric, detecting antibiotic resistance (Welsh Office) with J. Marshall Stark (Medical Microbiology, UWCM) |
39 | Joy Khunkitti | 1993-1996 (1996) | Acanthamoeba biocides (Thai Government) with Y. Aoki (Khon Kaen University, Thailand) and A. Denver Russell (Pharmacy, Cardiff University) |
38 | Duncan Edlin | 1993-1996 (1997) | Flavours and Fragrances: production using yeasts and filamentous fungi (AFRC) with Arjan Narbad (ARC Food Institute, Norwich) and JR Dickinson (Cardiff University) |
37 | Ian Williams | 1993-1996 (1996) | Plasmid loss in clinical isolates of Staphylococcus aureus (SERC-CASE, SmithKline Beecham) with WA Venables (Cardiff University) Frank Paul, Ian Critchley and Robert Jepras (Beechams SKB) |
36 | Gwenda Dinsdale | 1991-1992 (1995) | Yeast plasma membrane physiology and cider fermentation (SERC-CASE, Bulmers) with Basil Jarvis (Bulmers, Hereford) |
35 | Fred Kippert | 1990-1991 (1992) | Ultradian Cycles in Yeast (Self-financing) |
34 | Elizabeth Rees | 1990-1993 (1995) | Metabolism of rumen chytidomyces (SERC-CASE, Hannah Institute) with Alan G. Williams (Hannah Institute, Ayr) |
33 | David Mason | 1990-1993 (1995) | Detection of Antibiotic Resistance in Bacteria (Welsh Office) with M. Stark (Medical Microbiology, UWCM) and R. Allman |
32 | Michelle Humphreys | 1990-1993 (1994) | Metabolic Studies on Trichonomas vaginalis (SERC) with R. Allman |
31 | Katie Thomas | 1989-1992 (1993) | Mass spectrometric monitoring of gases in sediments (NERC) with Kelvin L. Davies |
30 | Sarah Finney | 1988-1991 (1992) | Biochemistry of Nematodes (SERC-CASE, Pfizer) with Ken (Pfizer, Kent) |
29 | Julie Benstead | 1987-1990 (1991) | Methanogenic cocultures: in species Ha transfer (SERC-IFR, Norwich) with David B. Archer (Pfizer, Kent) |
28 | Jayne Ellis | 1987-1990 (1990) | Metabolism of Rumen Ciliate Protozoa (SERC-Hannah) with Alan G. Williams (Hannah Institute, Ayr) |
27 | Chandra Gopal | 1985-1989 (1990) | Expressed recombinant genes and yeast energy metabolism (SERC-CASE, Celltech) with D. Broad (Celltech, Slough) |
26 | Helen Jenkins | 1984-1987 (1988) | Circadian and Ultradian Rhythms in Chlamydomonas and Euglena (SERC) with Alan J. Griffiths (Cardiff University) and J Woody Hastings. (Harvard, USA) |
25 | Richard Allman | 1984-1987 (1988) | Flow Cytometric analyses of bacteria (SERC-CASE, MOD, Porton) with A.P. Phillips (MOD Porton Down) |
24 | Kathryn J.P. Davies | 1984-1987 (1987) | Denitrification (NERC) with Lynne Boddy (Cardiff University) and W. Jack Payne (University of Georgia Athens, Georgia USA) |
23 | Eid Khalil | 1985-1987 (1987) | Studies on Anaerobic Digestion (Egyptian Government) with David E Hughes and Tim Whitmore (Cardiff University) |
22 | Timothy A. Paget | 1983-1987 (1986) | Electron Transport in mitochondria of parasitic helminths (SERC-CASE, Wellcome) with Mitchel Fry |
21 | Alan Chapman | 1983-1986 (1987) | Studies on the Biochemistry of Trichomonas vaginalis (SERC-CASE Wellcome) with David Linstead |
20 | Haifai Al' Obaidy | 1982-1985 (1986) | Host defence mechanisms in CAPD: a laboratory and clinical investigation (Self-supported) with Malcolm Davies (Renal Medicine, UWCM) |
19 | Kevin Hillman | 1982-1985 (1987) | Studies on Rumen Ciliate Protozoa (SERC-CASE Hannah Institute) with Alan G. Williams (Hannah Institute, Ayr) |
18 | David J. Hill | 1981-1984 (1985) | Regulation of enzyme levels in Candida species (Cardiff University Studentship) |
17 | Richard O. Jenkins | 1980-1983 (1984) | An investigation into the role of subcellular organelles in various species of yeasts (CNAA, Trent Polytechnic) with Trevor G. Cartledge (Trent University, Nottingham) |
16 | Pershing Abdul | 1982-1985 (1984) | Studies on Anaerobic Digestion (Iraqi Government) with David E Hughes (Cardiff University) |
15 | Nigel Yarlett | 1979-1982 (1982) | Metabolism of Dasytricha ruminantium, a rumen ciliate (SERC-CASE Hannah Institute) with Alan G. Williams (Hannah Institute, Ayr) |
14 | David Wales | 1977-1980 (1980) | Aspects of the Biochemistry of the Facultative Anaerobe Saccharomyces carlsbergensis (CNAA, Trent Polytechnic) with Trevor G. Cartledge (Trent University, Nottingham) |
13 | Mark Unitt | 1976-1979 (1980) | Energy Metabolism in Tetrahymena pyriformis Strain ST (SRC) |
12 | Zahra Toma | 1976-1979 (1980) | Mechanisms of enzyme instability in yeasts (Iraqi Government) |
11 | Steven W. Edwards | 1975-1978 (1978) | The Physiology of Growth of Acanthamoeba castellanii (MRC) with Alan J. Griffiths (Cardiff University) |
10 | Ghassan El' Khayat | 1976-1979 (1980) | Changes in Energy Conservation Systems During Growth and Starvation of Schizosaccharomyces pombe (Syrian Government) |
9 | Carol Phillips | 1972-1975 (1976) | The Cell Cycle of Tetrahymena pyriformis Strain ST (Cardiff University) |
8 | Merril Hammil | 1972-1975 (1976) | Studies of the Mitochondrial genome in Saccharomyces cerevisiae (Cardiff University) |
7 | Jalil Kader | 1972-1975 (1978) | Studies on synchronous cultures of Candida utilis (Malaysian Government) |
6 | Clive Edwards | 1971-1974 (1978) | Crithidia fasciculata (SRC) |
5 | Robert K. Poole | 1970-1973 (1973) | Structure and Function of the Fission yeast Schizosaccharomyces pombe (SRC) |
4 | Trevor G. Cartledge | 1969-1972 (1972) | Structure and Function of the yeast Saccharomyces carlsbergensis (MRC) |
3 | Rosemary Cooper | 1968-1971 (1971) | Structure and Function of the yeast Saccharomyces carlsbergensis (MRC) |
2 | Geoffrey Turner | 1967-1970 (1970) | The mitochondria of Tetrahymena pyriformis (MRC) |
1 | David A. Evans | 1965-1969 (1969) | Structure and Function in the colourless alga Polytomella caeca (MRC) with David E Hughes (Cardiff University) |
Post-Doctoral
No. | Name | Dates | Project |
22 | Victoria Gray | 2007-2011 | Modern Water Continuous environmental monitoring of water quality using bioluminescent bacteria. |
21 | David Pooley | 2010 | Software development |
20 | Francisco Gomez | 2008-2010 | Construction and maintenance of hardware and wireless operation for this monitor |
19 | Louise Thomas | 2002 (6 months) | Acanthameoba :treatment of eye infections |
18 | Douglas Murray | 1998-2000 | Yeast fermentation |
17 | Manfred Beckman | 1998-2001 | Peat bog gases |
16 | Alexander Dorofeev | 1997-1998 | Bioenergetis of synchronous yeast chemostat cultures (Royal Society/ |
15 | David Horner | 1995-1997 | Early branching eukaryotes (with Natural History Museum) |
13 | Katie Thomas | 1993-1996 | Methanogenesis in peat bogs |
12 | Simon Avery | 1992-1995 | Temperature adaptation in Acanthamoeba castellanii (NERC) |
12 | Andrew Rutter | 1993-1996 | Microsomal fatty acid desaturation (SERC) |
11 | Julie Benstead | 1992-1993 | Methanogenesis in peat bogs (NERC) |
10 | Jayne Ellis | 1990-1992 | Metronidazole and Giardia lamblia (Wellcome) |
9 | Lesley Jones | 1989-1991 | Temperature adaptation and membrane lipids of Acanthamoeba (NERC) |
8 | Richard Allman | 1989-1991 | Rapid detection of bacteria by flow cytometry (MOD) |
7 | Timothy A. Paget | 1986-1989 | Metabolism and Chemotherapy of Giardia lamblia (Wellcome) |
6 | Kevin Hillman | 1988-1989 | Brettanomyces: spoilage of soft drinks (AFRC) |
5 | David Gaunt | 1986-1988 | Brettanomyces: a spoilage of soft drinks (AFRC Cadbury-Schweppes) |
4 | Timothy Whitmore | 1984-1987 | Mass spectrometric monitoring and control of anaerobic digestion (AFRC) |
3 | Nigel Yarlett | 1983-1985 | Metronidazole action and resistance in Trichomonas vaginalis (Cardiff University) |
2 | Robert Scott | 1981-1983 | Continuous monitoring of dissolved gases by mass spectrometry (SERC Biotech.) |
1 | Steven W. Edwards | 1978-1980 | Oscillatory dynamics in Acanthamoeba castellanii Cell Cycle (Cardiff University) |