Dr Alison Paul
Senior Lecturer in Physical Chemistry, School of Chemistry
- paula3@cardiff.ac.uk
- +44 (0)29 2087 0419
- Fax:
- +44 (0)29 2087 4030
- Available for postgraduate supervision
Overview
- Polymer mediated drug-delivery systems
- Polymer-drug and polymer-protein conjugates
- Polymer excipients for inhalation drug delivery from hydrofluoroalkanes (HFAs)
- Physicochemical characterisation of macromolecules in solution
- Relationships between molecular structure, solution conformation and therapeutic function.
- Formulation in colloidal systems
- Emulsions, microemulsions and particle suspensions
- Self-assembling systems, including functionalised surfactants
For more information, click on the 'Research' tab above.
Links
See Also: Soft Matter Research Group
Biography
PhD University of Bristol (2001, J. Eastoe). Postdoctoral Research Associate, Cardiff University (2001-3). Postdoctoral Research Fellow, Royal Institute of Technology, Stockholm (2003-4). Postdoctoral Research Fellow, University of Bristol (2004-5). Senior Research Fellow & Project Manager Cardiff University (2005-6). Appointed as Lecturer in Physical Chemistry, Cardiff, in 2006.
Committees and reviewing
- Executive Board - Cardiff Institute of Tissue Engineering and Repair Learning
- Research Committee (Chair) - Cardiff Institute of Tissue Engineering and Repair Learning
Publications
We are currently unable to retrieve the list of publications. Visit our institutional repository.Teaching
CH0002 Thermodynamics, Kinetics and Equilibria
CH3105 Techniques and Methods in Chemistry
CH3205 Thermodynamics and Kinetics
CH3407 Advanced Materials
- Polymer mediated drug-delivery systems
- Polymer-drug and polymer-protein conjugates
- Polymer excipients for inhalation drug delivery from hydrofluoroalkanes (HFAs)
- Physicochemical characterisation of macromolecules in solution
- Relationships between molecular structure, solution conformation and therapeutic function.
- Formulation in colloidal systems
- Emulsions, microemulsions and particle suspensions
- Self-assembling systems, including functionalised surfactants
Our aim is to enhance understanding of interactions in pharmaceutical formulations, particularly the stabilising interactions between polymer molecules and fluorinated solvents (such as those used in pressurised metered-dose inhalers (pMDIs)), and also how polymer based drug delivery systems behave and interact within the body. To this end we study multi-component solutions designed to mimic the conditions encountered in the biological environment. This approach allows us to identify correlations between molecular architecture, solution behaviour and therapeutic activity. This in turn will facilitate the targeted design of future drug-delivery systems building on the structure-activity relationships developed.
Projects include the targeted synthesis of both model and therapeutically relevant polymer-drug and polymer-protein conjugates, and their extensive characterisation by NMR, UV-VIS/IR/fluorescence spectroscopy. Solution properties are studied by two dimensional NMR methods (relaxation and diffusion), neutron/light/X-ray scattering and reflection, including experiments at central facilities such as the Rutherford Appleton Laboratories, Oxford, UK and Institut-Laue-Langevin, Grenoble, France.
We also work collaboratively with UK and internationally based colleagues in pharmacy, dentistry, optometry, drug development, medicine, theoretical chemistry and physics.