Professor Cathy Holt

Biography

School of Engineering, Cardiff University, Wales, UK

Professor Cathy Holt is a Professor of Biomechanics and Orthopaedic Engineering, in the Biomedical Engineering Research Group, Cardiff School of Engineering, Cardiff University. She received her honours degree in Mechanical Engineering from University College Cardiff (1988), and her PhD from Cardiff University (1993), UK.

She is Director of the Musculoskeletal Biomechanics Research Facility (MSKBRF), and a member of the Medical Engineering Research Group. She is CoPI, and Directs the Biomechanics Research for the Biomechanics and Bioengineering Research Centre Versus Arthritis,  She is also PI for the UK wide OATech+ Network Plus (EPSRC), and a founding member of the UK Imaging OA Consortium. Her achievements and and commitment to internationally recognised Orthopaedic Biomechanics  research have been recognised recently by The Suffrage Science Award (2017 to 2019). She is a Fellow of the Institution of Mechanical Engineers and a Fellow of the International Orthopaedic Research Societies.

2019 -             Chair, Biomechanics & Orth Eng, School of Engineering, Cardiff

2011 - 19        Reader, Biomechanics & Orth Eng, School of Engineering, Cardiff

2007 - 08        Royal Academy of Engineering - Leverhulme Trust Senior Research Fellow

2007-             Honorary Research Fellow, Orthopaedics, Cardiff and Vale NHS Trust

2006 -            Senior Lecturer, Biomechanics & Orth Eng, School of Engineering, Cardiff

2002-05         Lecturer, Biomechanics and Materials, School of Engineering, Cardiff

1996-01         Senior RA, Motion Analysis Lab Manager, School of Engineering, Cardiff

1993-96         RA, EPSRC/MOD, Tribology, School of Engineering, Cardiff

1990-93         RA, EPSRC, Tribology, School of Engineering, Cardiff

1988-90         PGR Student, SERC, Tribology, School of Engineering, Cardiff

1987              Summer Placement, Joint European Torus, UKAEA, Abingdon, Oxford

Qualifications

1998              P.G.Dip. Clinical Gait Analysis, University of Strathclyde, Glasgow

1993              Ph.D. Mechanical Engineering, University of Wales, Cardiff

1988              B.Eng. (Hons.) 2:1 Mechanical Engineering, University College Cardiff

Significant achievements

• PI, EPSRC NetworkPlus, OATech+ track record for leading large research networks, recognition in field of osteoarthritis technology research, 4 CIs & >100 partners across engineering, science, medicine, NHS and Industry, (>£1M), 2016-19
• Founder, Co-PI, Manager & Director, Biomechanics Research, ARUK Biomechanics & Bioengineering Centre (ARUKBBC), non-competitive resubmission, translation, clinically important studies & sustained research income with > 50 academic/research staff & 20. MD/PhD students, (£4.5M ARUK/£7.5M CU), 2009 -19
• Chair, IMechE Biomedical Engineering Association Board, RAEng Biomedical Engineering Panel member; Biomedical Engineering Special Interest Group or IPEM/BES, 2016-
• PI/Project Lead, Musculoskeletal Biomechanics Research Facility (HEFCW/Welsh Government, £2.5M/ Cardiff University £2.5M), 2014
• EPSRC Assistive, Adaptive & Rehab Technology Sandpit, AARTBC funding (>£2M), 2014
• Speaker/Mentor, RAEng, Biomedical Engineering Futures, 2006 & 2014
• Chair, IMechE Biomed. Eng. Assoc. Board and Osthopaedic TAC
• IMechE/IET/IPEM Working Committee on Biomedical Engineering, 2012-14
• Co-Chair, IMechE, International Conf. Knee/Hip, London, 2013 - 2015
• BBC Academy, Women Experts media training, 2013
• International Shoulder Group Council, International Society of Biomechanics, 2011 -13
• IMechE Academic Assessment Committee; Academic and Industrial Assessor, 2011 -13
• Non-clinical member, British Elbow & Shoulder Society, 2011–13 and American ORS, 2014
• Royal Academy of Engineering/Leverhulme Trust Senior Research Fellowship, 2007- 08
• CEng, IMechE, with a direct recommendation to FIMechE, 2007
• Guest Editor, Special Editions: Intl. J. CMBBE, 2008; Proc. IMechE. Part H, 2009
• EPSRC College: Peer Review and Panel member (ongoing)

School, University and external management, administrative, leadership

• School of Engineering Administration: School Board; Staff Executive Committee; Chair, School E&D Committee; Lead School Athena Swan Application- 2007 – 2014 (Bronze), now AS Exec and Self Assessment Committees.
• University Administration: E&D Contacts liaison for School, CPSE Equality Forum member, The Way Forward Research Initiative.
• School of Engineering Research: Biomedical Engineering Research Group Leader, Health Security & the Digital World Research Theme, Line Manager: 3 academics/3 PDRAs.

Cross-University Research:

• Cardiff Institute of Tissue Engineering and Repair (CITER): Research, Management and Learning & Teaching Committee leading to Tissue Engineering & Repair MSc (2000-12).
• Founder, PI, Manager, Team Leader and now Biomechanics Research Director for the Arthritis Research UK Biomechanics and Bioengineering Centre of Excellence (£10M plus £2.5M, 6 University Schools, 2009 onwards)

External Commitments:

• Co-Chair, Intl. Conf. Knee and Hip Surgery and Rehab, IMechE, London, Nov 2013, 2015
• Chair, Orthop. Tech. Adv. Com., Biomedical Engineering Assoc. Board, IMechE, 2012-
• Chair, Biomedical Engineering Association Board, IMechE, 2016 -
• Biomedical Engineering SIG, IPEM/BES, 2016 -
• Chair, Annual Biomedical Engineering Student Competition, 2013- 16
• Elected, Intl. Shoulder Group Committee (ISB), 2011- 16
• FIMechE, CEng: Academic Assessment Committee and Assessor, 2011-
• Nominated/Elected - non-clinical member of British Elbow and Shoulder Society, 2011-
• Arthritis Research UK, OA & Crystal Diseases CSG, Ad-hoc Panel Advisor, 2011-
• Meditech Steering & Technical Committee: Medical technology network – academic /industrial partners including: ARUP, S&N, Simpleware, National Physical Laboratory

Referee, reviewer, higher degree examiner and academic recruitment

• Invited External Advisor and Examiner: Southampton University Biomed Eng Degree, 2016; Biomedical Engineering UG, Dublin City University (2010-15)
• PhD, MPhil and MSc Examiner/Reviewer: Imperial College (3), Bath (2), Leeds (2), Newcastle (2), Salford (1), Strathclyde (1), East Anglia (1), Birmingham (1), Northumbria (1), Cardiff (5), W. Australia (1), Sydney (1), Uni Tech MARA Malaysia (1), University of Brussels, KU Leuven (1)
• Academic Recruitment/Referee: Trinity College Dublin; Oxford; Newcastle (2009-14).
• Reviewer: RC -Sweden/Leuven Uni; BUPA; Roy. Coll. Surgeons; British Council, Furlong
• Journal Reviewer – many journals including Arth and Rheum, Bone Research Journal, J. Biomechanics; CORR, Gait & Posture; IMechE Proc, RS Interface, Plos One,
• Conference Abstract reviews: IMechE Inl. Knee/Hip Meetings, 2013/15, ICAME2010, Malaysia, 2010; ESB, Edinburgh, 2010; BORS 2010; CMBBE 2008-12, ORS (2015)
• Prize judge: IMechE Knee (2013), CMBBE (2008-12); BORS (2009-10); CITER
• Conference organiser/Technical Committee reviewer/Chair/Session Chair: ORS (2015), IMechE Knee/Hip/Upper limb (2013/15); ICCM2013, CMBBE (2008 - 12); ESB; UKSBG3 (2009 -12); Medical Devices Faraday Partnership-Orthopaedics (2006)
• Guest Editor: Journal Special Issues/Sections: Intl. J CMBBE, Motion Analysis and Musculoskeletal Modelling, Taylor & Francis, 2008; IMechE:H, Engineering the Upper Limb, 2009; J Strain. Analysis for Engineering Design, 2014 (In progress).

Honours and awards

Her achievements and and commitment to internationally recognised Orthopaedic Biomechanics  research have been recognised recently by The Suffrage Science Award (2017 to 2019).

As a Chartered Engineer (CEng), she is a Fellow of the Institution of Mechanical Engineers and a Fellow of the International Orthopaedic Research Societies.

She was awarded a Royal Academy of Engineering/Leverhulme Trust Senior Research Fellowship, 2007

Professional memberships

• IMechE: CEng FIMechE
• Chair BmEA Board, Chair Orthopaedics TAC, IMechE (2017 - 2019)
  • Chair, Annual Medical Engineering Student Competition,2013, 2017
  • Co-Chair IET/IMechE Annual Student Healthcare Technology Competitions 2014-15
  • Co-Chair, IMechE Knee and Hip conferences, 2013- 2015
  • RAEng Biomeical Engineering Panel member - now Healthcare Technology Policy Group
  • IPEM, Biomedical Engineering Special Interest Group
  • IPEM/IET/IMechE Biomeical Engineering Working Group
• EPSRC College (2006-): Peer Reviewer/Panel member
• Reviewer, BBSRC/MRC/Royal Society/Welcome Trust, ARUK, ORUK, Dunhill Trust (2012-).
• EU (2007) Intl Peer and Panel Review, Brussels, FP6 (2007) & FP7 (2013), H2020 (2017)
• ISB, ISG, ESB, ESMAC, BORS, ORS, OARSI membership- ongoing:

• Journal Special Issue, Guest Editor:
• International Journal of Computer Methods in Biomechanics and Biomedical Engineering (CMBBE): Motion Analysis and Musculoskeletal Modelling.
• Proceedings of the IMechE, Journal of Engineering in Medicine: Engineering the Upper Limb.

Academic positions

• Guest Lecturer
  • Leeds University, Biomechanics Course
  • Bath University, Advanced Biomechanics
  • UiTM Shah Alam Malaysia
  • medical Devices Lecture module at the Katholik University of Leuven, Belgium
• External examiner of MSc and MPhil at Leeds and Newcastle Universities.
• External examiner of PhD students at many UK universities including Bath, Imperial College London, Salford, Newcastle, Liverpool John Moores, Leeds, Strathclyde, Swansea, University of Western Australia

• External examiner for UG Degrees:
  • DCU, Dublin (2013 -2016)
  • QMUL, London (2017 -)

Speaking engagements

• 8th Intl Conf. Computer Methods in Biomechanics and Biomedical Engineering, Motion capture and analysis: from joint modelling and functional classification to novel applications to characterise the mechanical properties human tissues, Plenary Talk, Porto 2008
• Meditech, Facial imaging and mimicry using 3D motion capture, Plenary, Meditech, Paris 2009
• IMechE, Sensing and Measurement in Medicine, International Meeting, Using Motion Capture and Analysis to Explore the Mechanical Properties of Human Skin In-Vivo, London, 2009
• International Conference on Orthopaedic Surgery, Biomechanics and Clinical Applications, Objective classification of healthy & pathological joint function: application to the assessment of joint replacements, Brunel University, 2010
• IMechE, Changing role of engineers in orthopaedics, The role of motion analysis in the assessment of implants, London 2010,
• ICAME, Motion capture and analysis: from joint modelling and functional classification to novel applications to characterise the mechanical properties human tissues, Selangor 2010, Malaysia
• Meditech, Correlating knee joint loading with biological and pain indicators of osteoarthritis, , Anglia Ruskin University, 2012
• Inst of Physics, Modern Practice in Stress and Vibration Analysis: British Society for Strain Measurement (BSSM) Guest Lecture: Understanding osteoarthritis of the knee using combined analysis of functional, musculoskeletal and biological response to mechanical loading, Glasgow, 2012

Invited seminar and lectures

International:

• Florida and Stanford Universities, Biomechanics and biomaterials research at Cardiff, 2007
• Trinity College, Dublin, Biomechanics and biomaterials research at Cardiff: Current activities, developing research areas and future aspirations, Dublin, 2007
• Katholik University Leuven, Belgium, Biomechanics of the knee and hip, Leuven, 2011
• Technical University of Vienna, Investigating the Onset and Development of Osteoarthritis: Using Novel Patient Specific Modelling, Vienna, 2012

UK (2007 – 2012):

• Universities of Leeds, Bath, Newcastle, Brunel, Liverpool, Birmingham
• National Physical Laboratory, London
• IMechE Events in Bristol, Swansea and London.

Industry:

• DePuy Academy, Knee Biomechanics, Cardiff, 2010
• Ossur Academy, Knee joint biomechanical and biological changes following High Tibial Osteotomy, Cowbridge, S Wales, 2012
• Hospital Innovations, Training Afternoon, Knee Biomechanics, 2014

Conference chair, keynotes and plenaries

• Member of the Technical Organising Committee for CMBBE 2012 Berlin, 2010, Valencia,
• Member of the Organising Committee for BORS 2010, Cardiff, UK
• Member of the International Advisory Committee for ICAME 2010, Selangor, Malaysia

• Session Leader and Chair for the International Symposium on Computer Methods in Biomechanics and Biomedical Engineering CMBBE 2006, 2008 and 2010
• Session Leader and Chair for the International Conference on Orthopaedic Surgery, Biomechanics and Clinical Applications (2010)
• Abstract Reviewer and Chair for 2 sessions for the 17th European Society of Biomechanics Congress, Edinburgh (2010)
• Session Chair for British Orthopaedics Research Society BORS (2010)
• Session Chair for the 3rd International Conference on Advances in Mechanical Engineering ICAME Selangor, Malaysia (2010)

• Invited plenary talks at CMBBE, Porto 2008; Meditech, Paris 2009; Sensing & Measurement in Medicine, IMechE International Meeting, London 2009 and Changing Role of Engineers in orthopaedics, London 2010, and ICAME, Selangor 2010
• IoP, British Society of Strain Measurement, Plenary, Glasgow 2012
• Presented numerous papers at international conferences in the UK, USA and Europe
• Published over 100 peer-reviewed journals papers and conference proceedings

Publications

We are currently unable to retrieve the list of publications. Visit our institutional repository.

Teaching

Biomechanics 1 Year 2) - Basic Biomechanics of the Musculoskeletal System

Biomechanics 2 (year 3) - Applicaition in Biomechanics of the Musculoskeletal System

Design (Year 2) - Enginerring Design Make and Test with industry partners

Egonomics (Year 4)

Year 3 Individual Projects

Clinical Teaching for Cardiff and Vale orthopaedic Centre - Training and Regsitry teaching

Holt, C. and Williams, D. 2018. Chapter 6: Biomechanics of the peripheral joints. In: Hochberg, M. C. et al. eds. Rheumatology, 2-Volume Set - 7e., Vol. 7e. Elsevier

Research theme: Health, Technology and the Digital World

Contracts

Title	People	Sponsor	Value	Duration
10th Meeting: technical group on '3D analysis of human movement' International Society of Biomechanics.	Holt CA	Royal Society	790	28/10/2008 - 28/07/2009
Gait analysis of knee inplants	Dr CA Holt	DePuy UK	44898	05/01/2002 - 04/01/2004
Development of a constitutive model for the peridontal ligament using a novel motion analysis technique	Evans SL, Holt CA	Engineering and Physical Sciences Research Council	158133	01/09/2003 - 31/08/2006
Cardiff Institute of Biomechanics and BioEngineering Research (CIBER)	Holt CA, Evans SL, with BIOSI, MEDIC, SOHCS, DENTL, PHRMY & PSYCH	Arthritis Research Campaign	509987	01/08/2009 - 01/08/2014
Clinical validation of a new mathematical tool to classify normal pathological knee function	Holt CA, (with CARBS & MEDIC)	Medical Research Council	27604	01/07/2004 - 30/06/2005
Kinematic analysis of normal and pathological shoulder function: A study of the measurement accuracy and validity for use in objective functional classifiers	Dr CA Holt	Plus Orthopaedics (UK) Ltd	50000	01/10/2006 - 30/09/2009
Using motion analysis techniques and objective classifiers to characterise mechanisms of human movement and postural control: Applications to orthopaedics and neurology	Dr CA Holt	Royal Academy of Engineering	34562	01/09/2007 - 01/09/2008
The clinical validation of a new mathematical tool to diagnose and classify normal, pathological and TKR knee function	Dr CA Holt, (with CARBS & COMSC & MEDIC)	Engineering and Physical Sciences Research Council	86836	01/05/2005 - 31/10/2007
Investigation of gait and functional activities using 3D motion analysis in patients with knee osteoarthritis and in normal healthy volunteers	Sparkes V, Holt C, Whatling G	GlaxoSmithKline Consumer Healthcare Pte Ltd	76383.5	09/06/2014 - 31/03/2015
Human motion analysis of new knee	Dr LDM Nokes, Dr CA Holt	DePuy UK	15000	01/01/2001 - 01/01/2004
Automated assessment of timing and movement signatures in Huntingdon's disease	Busse (HCARE) Holt C, Hicks Y	Wellcome Trust	16301	01/01/2016 - 31/12/2016
Adaptive assistive rehabilitative technology: Beyond the Clinic (AART:BC)	Holt C	EPSRC via Warwick	192476	01/04/2015 - 31/03/2018
Implementation of the development of single protein fibre matrix composties for high performance cartilage repair device	Holt C	Technology Strategy Board	90834	01/02/2013 - 31/01/2015
Predicting and evaluating the surgical outcome following high tibial osteotomy using musculatoskeletal modelling, objective classification, imaging and biological mtesting	Holt C	ARTHREX Ltd	49500	01/03/2010 - 28/02/2014
OsteoArthritis Technologies Network Plus (OATech+): A multidisciplinary approach to the prevention and treatment of osteoarthritis	Holt C	EPSRC	968486	01/07/2016 - 30/06/2020
Functional and Biological Assessment of a New Implant Material to Treat Focal Cartilage Defects	Holt C, Mason D (BIOSI)	Ser Cymru NRN AEM	28500	01/04/2014 - 31/03/2017
ARUK Biomechanics & Bioengineering Centre	Holt C, Whatling G, Evans S	Arthritis Research UK	420000	01/01/2016 - 31/12/2020
Musculoskeletal Research Centre	Holt C, Whatling G, Jones P, Mitchard D	Welsh Government	2500000	01/04/2015 - 31/03/2017
The relationship between alignment, function and loading in total knee replacement: In-vivo analysis of a unique patient population	Holt C, Whatling G, Roberts H (BIOSI)	Furlong Research Charitable Foundation	29562	01/08/2011 - 31/07/2012
Clinical validation of a new mathematical tool to diagnose and classify normal pathological TKR knee function	Holt CA	DePuy UK	45000	01/10/2005 - 30/09/2008
The clinical validation of a new mathematical tool to diagnose and classify normal, pathological TKR knee function	Holt CA	DePuy International Ltd	50000	01/04/2009 - 31/03/2012
Digital image correlation as a technique to validate finite element models	Holt CA	Royal Society	1600	01/03/2008 - 02/05/2008
Clinical validation of a new mathematical tool to diagnose and classify normal pathological TKR knee function	Holt CA	DePuy UK	20000	01/10/2005 - 31/12/2008
Arthritis Research UK Biomechanics and Bioengineering Centre	Duance V, Caterson B, Mason D, Blain E, Evans B, Williams A, Jones S, Birchall J, Van Deursen R, Sparkes V, Aeschlimann D, Wise R, Holt C, Evans S, Whatling G	Arthritis Research UK	19974	01/10/2014 - 31/03/2015

Supervised Students

Title	Student	Status	Degree
Modelling of Metal on Metal Hip Prostheses	AL SAFFAR Ali Abd Al-Ameer Hussien	Graduate	PhD
Knee Osteoarthritis is a Bilateral Disease	METCALFE Andrew John	Graduate	MD
BIOMECHANICAL LOADING OF THE KNEE JOINT - MEDICAL ENGINEERING.	GHAZWAN Aseel Mohammed Ali Hussein	Current	PhD
Functional Analysis of the Shoulder Complex in Healthy and Pathological Subjects using Three-Dimensional Motion Analysis Techniques	LOVERN Barry	Graduate	PhD
Development Of Novel Methodologieas To Quantify, Analyse And Classifiy In-Vitro Knee Function Affected By Aging, Osteoarthritis And Total Knee Replacement	WATLING Daniel	Graduate	PhD
A Contribution To The Clinical Validation Of A generic Method For The Classification Of Osteoarthritic And Non-Pathological Knee Function	WHATLING Gemma Marie	Graduate	PhD
DYNAMIC MODELLING OF THE SHOULDER COMPLEX (MEDICAL ENGINEERING).	LAFTA Hassanain Ali	Current	PhD
Development of Novel System to Measure and Calculate Tooth Movements for Studying the Properties of Periodontal Ligament	LIU Helen	Graduate	PhD
DATA FUSION OF RELATIVE MOVEMENT IN FAST REPETITIVE- ACTION SPORTS USING BODY WIRELESS AREA NETWORKS.	ARMSTRONG Helen Sian	Graduate	PhD
TBC	EVERITT Holly	Graduate	PhD
The Development Of A Novel Technique In Measuring Human Skin Deformation In Vivo To Determine Its Mechanical Properties	MAHMUD Jamaluddin	Graduate	PhD
Development Of A Finite Element Model Of The Knee Using Patient Specific Magnetic Resonance Imaging Data And Biomechanical Testing Of Soft Tissues	LI Joanna Yuen Sai	Graduate	PhD
A Novel Protocol For The Quantification Of Temproal And Postural Gait Parameters Of Rats And Humans	MADETE June Kazira	Graduate	PhD
The Development of a Novel Method for the Classification of Osteoarthritic and Normal Knee Function	JONES Lianne	Graduate	PhD
In Vivo Measurment And Objective Classification Of Healthy, Injured And Pathological Shoulder Injury	STROUD Lindsay	Graduate	PhD
Functional and Biological Assessment of a New Implant Material to Treat Focal Cartilage Defects	KHATIB Nidal	Current	PhD
THE EFFECTS OF LOADING AND ALIGNMENT ON JOINT STRUCTURES DURING FUNCTIONAL ACTIVITIES AND EXERCISES IN KNEE PATIENTS AND HEALTHY SUBJECTS	BIGGS Paul Robert	Current	PhD
An Investigation to Establish How The Evolution of Rugby Influences The Risk of Spinal Injury During Scrummaging	SWAMINATHAN Ramesh	Thesis Submitted	PhD
Novel Approaches To The Development Of PMMA Bone Cements	AYRE Wayne	Graduate	PhD

Supervision

Current supervision

Past projects