Daniel Maddison

Overview

Dr. Daniel Maddison completed a BSc in Biological Sciences and an MSc in Molecular Genetics at University of Leicester. During these studies, he worked in the labs of Prof. Charalambos Kyriacou & Dr. Ezio Rosato in the field of circadian rhythms and with Prof. Flaviano Giorgini, working on Drosophila models of Huntington's disease. 

Daniel continued to obtain his PhD in the lab of Prof. Giorgini, investigating interactions between the Kynurenine pathway of tryptophan metabolism and mitochondrial quality control mechanisms in Drosophila melanogaster and mamallian cell models. He identified a novel interaction between the enzyme Kynurenine 3-monooxygenase (KMO), a genetic modifier of Huntington's disease, with Parkinson's associated proteins PINK1 & PRKN. 

Upon completion of his PhD in 2018, Dr. Maddison joined the UK Dementia Research Institute (UK DRI) at Cardiff University, as a Research Associate in the lab of Dr. Gaynor Smith. He is interested in the mechanisms by which mitochondria are regulated in the nervous system, performing unbiased genetic screens in Drosophila to identify novel modulators of mitochondrial form & function. Daniel also has a strong interest in genetic risk factors for neurodegenerative disease and how these factors convey risk of developing disease.