Dr Dobril Ivanov
Sêr Cymru II Fellow, Dementia Research Institute
- ivanovd1@cardiff.ac.uk
- 1st floor, office 9, Hadyn Ellis Building, Maindy Road, Cardiff, CF24 4HQ
Overview
With a background in molecular biology, genetics and biostatistics/bioinformatics, Dr Dobril Ivanov joined the UK DRI at Cardiff with a Sêr Cymru Rising Star fellowship by the ERDF through the Welsh Government.
Dobril did an MSc in molecular biology followed by a wet-lab scholarship to study neurodevelopmental disorders at the MRC Centre in Cardiff. This project was one of the earliest to accurately estimate the frequency of VCFS deletions in patients with psychosis (https://doi.org/10.1192/bjp.183.5.409).
Dr Ivanov obtained his PhD in bioinformatics from Cardiff University in 2010, with one of the first studies to fully explore the similarities and differences of germline/somatic mutations in human tumour suppressor genes in a variety of cancers (https://doi.org/10.1002/humu.21483). During his first postdoc (MRC CNGG Cardiff University) he developed a novel computational approach that led to the observation that rare CNVs substantially increase one’s susceptibility to developing schizophrenia (https://doi.org/10.1038/mp.2011.154).
Dr Ivanov completed his postdoctoral training at the European Bioinformatics Institute in Cambridge in Prof. Janet Thornton’s group investigating neurodegenerative disorders and signalling mechanisms and biochemical processes by which insulin/IGF-1 signalling modulates lifespan in model organisms (https://doi.org/10.1016/j.celrep.2016.03.041). As a UK DRI Emerging Leader, Dr Ivanov leads research to link gene-expression profiles to a wide-range of Alzheimer-related phenotypes in humans, animal and iPSC models.
Biography
Previous Academic Positions
2018 - present: The Welsh Government Sêr Cymru II "Rising Star" fellow (UK Dementia Research Institute @ Cardiff University)
2012 - 2018: Postdoctoral Fellow - Thornton group (EMBL-EBI, European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus, Cambridge)
2011 - 2012: Research Associate in Bioinformatics (Biostatistics and Bioinformatics Unit, MRC Centre in Neuropsychiatric Genetics and Genomics, Cardiff University)
2008 - 2011: Research Associate in Statistical Genetics (Biostatistics and Bioinformatics Unit, MRC Centre in Neuropsychiatric Genetics and Genomics, Cardiff University)
2005 - 2010: PhD in Bioinformatics/Biostatistics ("Comparative analysis of Germline and Somatic micro-lesion mutational spectra in 17 human tumour-suppressor genes", Institute of Medical Genetics, Cardiff University)
2003 - 2005: Research Assistant (Department of Psychological Medicine and Neurology; MRC Centre in Neuropsychiatric Genetics and Genomics, Cardiff University)
2002 - 2003: Visiting Scholarship (Study on Juvenile Onset Psychosis, Cardiff University)
Honours and awards
2021: Emerging leader status (UK Dementia Research Institute)
2018 - present: The Welsh Government Sêr Cymru II "Rising Star" fellowship (Deconvoluting the Dementia Phenotype Using Functional Genomics and Computational Approaches)
2015: Experimental validation of lifespan extension of GWAS top hits (EMBL-EBI)
2011: Early Career Researcher Award (BSRA)
2002 - 2003: Visiting Scholarship, Study on Juvenile Onset Psychosis (Cardiff University)
Professional memberships
2018 - present: Alzheimer Research UK (ARUK) Wales Network member
2016 - present: British Society of Research on Ageing (BSRA) member
Publications
We are currently unable to retrieve the list of publications. Visit our institutional repository.Teaching
2008 - 2011 Module leader of "Introduction to statistical approaches in life sciences" (postgraduate course, MSc module, MRC Centre in Neuropsychiatric Genetics and Genomics, Cardiff University)